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Chronic oral administration of high doses of levocarnitine in patients with severely impaired renal function or end-stage renal disease (ESRD) and dialysis patients may lead to accumulation of the potentially toxic metabolites trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), as these metabolites are normally excreted in the urine

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Combined with monitoring urine color, eating water-rich foods, and limiting dehydrating beverages like excess caffeine, most tirzepatide users maintain adequate hydration without complications

To view a copy of this license, visit About this article Cite this article Tan, M., Yin, Y., Ma, X